Graft prosthesis, material and methods
AssigneesCook Biotech Incorporated, Cook Medical Technologies LLC
InventorsWilliam A. Cook, Michael C. Hiles, Thomas G. Kozma, Umesh H. Patel
Life of this patent
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Abstract
A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and removal steps to deactivate and remove contaminants, thereby making the purified structure biocompatible and suitable for grafting on and/or in a patient.
Claims16
A collagen-containing matrix obtained from a submucosa tissue source, comprising:
- a collagen-containing matrix obtained from a submucosa tissue source from urinary tract tissue, the collagen-containing matrix including submucosa tissue and lamina propria tissue from the tissue source, wherein the submucosa tissue has been separated from tunica muscularis tissue that was present in the submucosa tissue source;
- wherein said collagen-containing matrix exhibits a bioburden of less than 0.5 colony forming units per gram;
- and
- wherein said collagen-containing matrix retains growth factors from said tissue source, and said growth factors include basic fibroblast growth factor.
A method for treating a patient, comprising:
- providing a collagen-containing matrix obtained from a submucosa tissue source, the collagen-containing matrix comprising:
- a collagen-containing matrix obtained from a submucosa tissue source from urinary tract tissue, the collagen-containing matrix including submucosa tissue and lamina propria tissue from the tissue source, wherein the submucosa tissue has been separated from tunica muscularis tissue that was present in the submucosa tissue source;
- wherein said collagen-containing matrix exhibits a bioburden of less than 0.5 colony forming units per gram;
- and
- wherein said collagen-containing matrix retains growth factors from said tissue source, and said growth factors include basic fibroblast growth factor;
- and treating a partial or full thickness dermal wound of the patient with the collagen-containing matrix.
Dependencies are inferred from the claim text.