Oligonucleotide-containing pharmacological compositions and their use

A composition suitable for administration in a mammal suffering from a pathological disorder or disease comprising two or more modified oligonucleotides, wherein

• a.) a first and a second modified oligonucleotide each comprise about seven to seventy-five nucleotides containing seven or more contiguous ribose groups linked by achiral 5′ to 3′ internucleotide phosphate linkages, wherein said ribose groups of said modified oligonucleotides have a 2′ modification, and wherein said 5′ and 3′ ends of said modified oligonucleotides are blocked;
• b.) said first modified oligonucleotide is complementary to a region of a first gene associated with said pathological disorder or disease and said second modified oligonucleotide is complementary to a region of a second gene associated with said pathological disorder or disease, wherein the sequence of each of said modified oligonucleotides is selected from the group consisting of SEQ ID NO:
• 1, SEQ ID NO:
• 6, SEQ ID NO:
• 10, SEQ ID NO:
• 12 and SEQ ID NO:
• 24;
• and
• c.) wherein said first and second modified oligonucleotides are present in a total amount of less than about 7 mg.