Methods for treatment of cancer
AssigneeThe Trustees of the University of Pennyslvania
InventorsCarl H. June, Bruce L. Levine, David L. Porter, Michael D. Kalos, Michael C. Milone
Life of this patent
Estimating the term…
Abstract
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain.
Claims28
A method of treating leukemia in a human patient, the method comprising administering to the human patient a pharmaceutical composition comprising an anti-tumor effective amount of a population of modified autologous human T cells, wherein the T cells comprise a nucleic acid sequence that encodes a chimeric antigen receptor (CAR), wherein the CAR comprises a CD19 antigen binding domain, a CD8α hinge domain, a CD8α transmembrane domain, a CD27 costimulatory signaling region, and a CD3 zeta signaling domain.
Dependencies are inferred from the claim text.