Back to results
US 8,916,365 B2Granted
Expression of cytosolic malic enzyme in transgenic Yarrowia to increase lipid production
AssigneeE. I. Du Pont de Nemours and Company
InventorsDaniel Joseph Macool, Zhixiong Xue, Quinn Qun Zhu
Life of this patent
Estimating the term…
Abstract
Transgenic Yarrowia species are disclosed herein that comprise a polynucleotide encoding a cytosolic malic enzyme, a lipid content that is at least about 35% by weight of the dry cell weight of the Yarrowia species, and an engineered polyunsaturated fatty acid (PUFA) biosynthetic pathway, wherein overexpression of the cytosolic malic enzyme increases lipid content.
Claims19
A transgenic Yarrowia species comprising:
- (i) a polynucleotide encoding a cytosolic malic enzyme;
- (ii) a lipid content that is at least about 35% by weight of the dry cell weight of said Yarrowia species;
- and
- (iii) an engineered polyunsaturated fatty acid (PUFA) biosynthetic pathway,
- wherein overexpression of the cytosolic malic enzyme increases lipid content.
2 more elements
Dependencies are inferred from the claim text.