Bi-layered bone-like scaffolds
AssigneeBoard of Regents, The University of Texas System
InventorsDaniel Sunho Oh, Anson Ong
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Abstract
Biomedical scaffolds are described that may be used, for example, for the treatment of bone diseases and bone reconstruction and restoration. The described scaffolds having ingress and habitiaion property for cells and growth factors with serum by capillary action via engineered micro-channles. Also, the scaffolds permit nutrient and ion flow such that bone regeneration in the area surrounding the scaffold is promoted. Kits that include such scaffolds and methods of preparing and using such scaffolds are also provided.
Claims29
A method of making a bond-like scaffold having a core component and a cortical layer, comprising:
- a) contacting a core polymer porous template and a cortical layer polymer porous template disposed at least partially about the core polymer template with a composition comprising a calcium phosphate, alumina, or zirconia, wherein at least a portion of the core polymer porous template and the cortical layer porous polymer template become coated with the composition;
- and
- (b) drying the composition coated core polymer porous template and the cortical layer polymer porous template, where a bone-scaffold having a core component and a cortical layer disposed at least partially around the core component is formed.
Dependencies are inferred from the claim text.