System and method for determining individualized medical intervention for a disease state
AssigneeCaris MPI, Inc.
InventorsDaniel D. Von Hoff, Robert J. Penny
Life of this patent
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Abstract
A system and method for determining individualized medical intervention for a particular disease state, and especially for cancers, that includes the molecular profiling of a biological sample from the patient, determining whether any molecular findings including one or more genes, one or more gene expressed proteins, one or more molecular mechanisms, and/or combinations of such exhibit a change in expression compared to a reference, and identifying a non-specific disease therapy or agent capable of interacting with the genes, gene expressed proteins, molecular mechanisms, or combinations of such molecular findings that exhibited a change in expression.
Claims18
A method for determining a personalized medical intervention for an individual having a diagnosed pancreatic cancer comprising the steps of:
- a. measuring a molecular profile of at least one sample of the individual's pancreatic cancer comprising at least one of nucleic acid and protein analysis for each of the members of the molecular profile, wherein the members of the molecular profile comprise ERBB2, ESR1, TOP1, KIT, and EGFR;
- b. comparing the results of the at least one of nucleic acid and protein analysis in step a) to a reference to determine which members of the molecular profile exhibit a change as compared to the reference;
- c. accessing a computer database to identify at least one drug therapy that interacts with each of the members of the molecular profile that exhibited a change as compared to the reference in step b);
- and
- d. providing a computer generated report that indicates the at least one drug therapy identified in step c).
Dependencies are inferred from the claim text.