Elemental flow cytometer
AssigneePerkinElmer Health Sciences, Inc.
InventorsDmitry R. Bandura, Vladimir I. Baranov, Scott D. Tanner
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Abstract
An elemental flow cytometer includes a device to vaporize, atomize, and ionize material and an introduction system for introducing packets of discrete entities into said device to vaporize, atomize and ionize materials to vaporize, atomize and ionize the entities in the packets. A spectrometer is adapted to individually analyze elemental composition of one or more of the vaporized, atomized and excited or ionized packets.
Claims24
An elemental flow cytometer, comprising:
- a device to vaporize, atomize, and ionize material;
- an introduction system for introducing packets of discrete entities into said device to vaporize, atomize and ionize materials to vaporize, atomize and ionize the entities in the packets;
- and
- a spectrometer adapted to individually analyze elemental composition of one or more of the vaporized, atomized and excited or ionized packets,
- wherein the mass spectrometer is adapted to detect transient signals produced by analysis of distinct ion clouds associated with the ionization of individual packets and to maintain data relating to an individual packet distinct from data relating to other packets to enable analysis of the contents of the individual packets.
An elemental flow cytometer, comprising:
- a device to vaporize, atomize, and ionize material;
- an introduction system for introducing packets of discrete entities into said device to vaporize, atomize and ionize materials to vaporize, atomize and ionize the entities in the packets;
- and
- a spectrometer adapted to individually analyze elemental composition of one or more of the vaporized, atomized and excited or ionized packets,
- wherein the introduction system comprises an in-line lysis system.
An elemental flow cytometer, comprising:
- a device to vaporize, atomize, and ionize material;
- an introduction system for introducing packets of discrete entities into said device to vaporize, atomize and ionize materials to vaporize, atomize and ionize the entities in the packets;
- a spectrometer adapted to individually analyze elemental composition of one or more of the vaporized, atomized and excited or ionized packets, and
- an ion pre-treatment system adapted to transportions from the device to vaporize, atomize, and ionize to the mass analyzer, wherein the ion pretreatment system comprises a high pass ion guide adapted to limit transportation of plasma support gas ions to the mass analyzer.
An elemental flow cytometer, comprising:
- a device to vaporize, atomize, and ionize material;
- an introduction system for introducing packets of discrete entities into said device to vaporize, atomize and ionize materials to vaporize, atomize and ionize the entities in the packets;
- a spectrometer adapted to individually analyze elemental composition of one or more of the vaporized, atomized and excited or ionized packets;
- and
- a trigger system adapted to trigger a detection system of the mass analyzer to acquire data associated with a discrete packet in response to detection by the trigger system of an event associated with an ion cloud produced as the discrete entities in said packet are ionized by the device to vaporize, atomize, and ionize.
Dependencies are inferred from the claim text.