Transgenic pig model of cystic fibrosis
AssigneesUniversity of Iowa Research Foundation, The Curators of the University of Missouri
InventorsMichael J. Welsh, Christopher S. Rogers, Randall S. Prather, John Engelhardt, Ziying Yan
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Abstract
The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of making and using such animal models in the identification and characterization of therapies for the diseases and conditions.
Claims10
A transgenic pig whose genome comprises a homozygous deletion of the codon for phenylalanine at position 508 of the CFTR protein of said pig, wherein said pig has a symptom of cystic fibrosis in its pancreas, intestine, liver, or gall bladder, and does not express wild-type CFTR.
Dependencies are inferred from the claim text.