Back to results
US 8,912,360 B2Granted
Methods for preparing ritodrine hydrochloride
AssigneeLundbeck Pharmaceuticals Italy S.P.A.
InventorsJacopo Zanon, Giovanna Libralon, Carla De Faveri, Florian Anton Martin Huber
Life of this patent
Estimating the term…
Abstract
Methods for preparing Ritodrine hydrochloride are provided. Also provided is non-hygroscopic, crystalline, polymorphic Ritodrine hydrochloride of Form I.
Claims6
A method for preparing ritodrine hydrochloride comprising:
- (a) reacting of 4-(2-bromopropionyl)phenyl methanesulfonate with benzyl-[2-(4-benzyloxyphenyl)-ethyl]-amine to obtain 4-(2{benzyl-[2-(4-benzyloxy-phenyl)-ethyl]-amino}-propionyl)-phenyl methanesulfonate;
- (b) hydrolyzing of 4-(2-{benzyl-[2-(4-benzyloxyphenyl)-ethyl]-amino}-propionyl) -phenyl methanesulfonate to obtain 2-{Benzyl-[2-(4-benzyloxyphenyl)-ethyl]-amino}-1-(4-hydroxy-phenyl)-propan-1-one;
- (c) salificating of 2-{Benzyl-[2-(4-benzyloxyphenyl)-ethyl]amino}-1-(4-hydroxy -phenyl-propan-1-one;
- and
- (d) catalytically hydrogenating of 2-{Benzyl-[2-(4-benzyloxyphenyl)-ethyl]-amino}-1-(4-hydroxy-phenyl)-propan-1-one hydrochloride to obtain Ritodrine hydrochloride as an erythro/threo mixture about of 98:2.
2 more elements
Dependencies are inferred from the claim text.