Aryl and heteroaryl sulfones as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
AssigneeVanderbilt University
InventorsP. Jeffrey Conn, Craig W. Lindsley, Corey R. Hopkins, Charles David Weaver, Colleen M. Niswender, Yiu-Yin Cheung
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Abstract
In one aspect, the invention relates to sulfone compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
Claims16
A compound of a structure represented by the following formula:
- wherein:
- X1 is S or SO2;
- R1 is pyridine optionally substituted with one or more R8;
- R4 is phenyl optionally substituted with one or more R8;
- R5 and R6 are H;
- R7 is selected from:
- H, halogen, C1-6 alkyl, C3-10 cycloalkyl, OC1-6 alkyl, aryl, heteroaryl, CN or CF3;
- R8 is selected from:
- H, OH, halogen, C1-6 alkyl, C3-10 cycloalkyl, CN, OC1-6 alkyl or CF3;
- or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising a compound of the following formula:
- wherein:
- X1 is S or SO2;
- R1 is pyridine optionally substituted with one or more R8;
- R4 is phenyl optionally substituted with one or more R8;
- R5 and R6 are H;
- R7 is selected from:
- H, halogen, C1-6 alkyl, C3-10 cycloalkyl, OC1-6 alkyl, aryl, heteroaryl, CN or CF3;
- R8 is selected from:
- H, OH, halogen, C1-6 alkyl, C3-10 cycloalkyl, CN, OC1-6 alkyl or CF3;
- or a pharmaceutically acceptable salt thereof;
- and a pharmaceutically acceptable carrier.
A compound of the following formula:
- or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising a compound of the following formula:
- or a pharmaceutically acceptable salt thereof;
- and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.