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US 8,912,324 B2Granted
Optically active pyrazolylaminoquinazoline, and pharmaceutical compositions and methods of use thereof
AssigneeAmbit Biosciences Corporation
InventorsMark W. Holladay, Eduardo Setti
Life of this patent
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Abstract
Provided herein is an optically active pyrazolylaminoquinazoline, and pharmaceutical compositions thereof. Also provided herein is a method for treating, preventing, or ameliorating one or more symptoms of a JAK-mediated condition, disorder, or disease. Further provided herein is a method for treating, preventing, or ameliorating one or more symptoms of a proliferative disease, inflammatory disease, or renal disease.
Claims19
An optically active (S)-(4-fluorophenyl)(4-((5-methyl-IH-pyrazol-3-yl)amino)quinazolin-2-yl)methanol or an isotopic variant thereof;
- or pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof;
- wherein the compound has an enantiomeric excess of no less than 80%.
Dependencies are inferred from the claim text.