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US 8,912,315 B2Granted
Purkinje cell-tropic viral vector
AssigneeJapan Science and Technology Agency
InventorsHirokazu Hirai, Takashi Torashima
Life of this patent
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Abstract
The present invention relates to a Purkinje cell-tropic viral vector in which a modified L7 promoter and a therapeutic gene are operably linked to a virus-based plasmid vector.
Claims19
A cerebellar Purkinje cell-tropic vector comprising a L7 promoter operably linked to a foreign gene operably linked to a virus-based plasmid vector, wherein the L7 promoter is selected from the group consisting of:
- a) a DNA consisting of the nucleotide sequence shown in SEQ ID NO:3,
- b) a DNA consisting of the nucleotide sequence shown in SEQ ID NO:4, and
- c) a DNA consisting of a nucleotide sequence fragment of SEQ ID NO:3 that contains at least the nucleotide sequence of 317 to 1322 of SEQ ID NO:
- 1.
1 more element
Dependencies are inferred from the claim text.