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US 8,912,311 B2Granted
Generation of a cancer-specific immune response toward MUC1 and cancer specific MUC1 antibodies
AssigneesKøbenhavns Universitet, Cancer Research Technology Limited
InventorsHenrik Clausen, Joy Burchell, Ulla Mandel, Anne Louise Sørensen, Mads Agervig Tarp, Joyce Taylor-Papadimitriou
Life of this patent
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Abstract
The present invention provides a method for inducing a cancer specific immune response against MUC1 using an immunogenic glycopeptide. Other aspects of the invention are a pharmaceutical composition comprising the immunogenic glycopeptide and a cancer vaccine comprising the immunogenic glycopeptide. Another aspect is an antibody generated using the immunogenic glycopeptide and the use of said antibody in therapy and diagnosis.
Claims4
A monoclonal antibody
- which binds to and interacts directly with an O-glycosylated GSTA motif (SEQ ID NO:
- 7), and which antibody binds MUC1 on cancer cells but not MUC1 on a non-malignant counterpart.
Dependencies are inferred from the claim text.