Polyol-based polymers
AssigneeMassachusetts Institute of Technology
InventorsJoost P. Bruggeman, Christiaan Nijst, Daniel S. Kohane, Robert S. Langer
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Abstract
The present invention provides inventive polyol-based polymers, materials, pharmaceutical compositions, and methods of making and using the inventive polymers and materials. In certain aspects of the invention, an inventive polymer corresponds to a polymer depicted below. Exemplary inventive polymers includes those prepared using polyol units (e.g., xylitol, mannitol, sorbitol, or maltitol) condensed with polycarboxylic acid units (e.g., citric acid, glutaric acid, or sebacic acid). The inventive polymers may be further derivatized or modified. For example, the polymer may be made photocrosslinkable by adding methacrylate moieties to the polymer.
Claims24
A polymer, wherein the backbone consists of alternating polyol and polycarboxylic acid units, wherein:
- monomers used to form the polymers are selected from the group consisting of alkanedioic acids having two carboxylic acid groups and sugar alcohols comprising at least four hydroxyl groups;
- and
- the ratio of the sugar alcohol units to the alkanedioic acid units in the polymer is 1 unit of sugar alcohol to at least 2 units of alkanedioic acid.
A polymer, wherein the backbone consists of alternating polyol and polycarboxylic acid units, wherein:
- monomers used to form the polymers are selected from the group consisting of alkanedioic acids having two carboxylic acid groups and sugar alcohols comprising at least four hydroxyl groups;
- one or more of the hydroxyl groups in the polymer has been modified with one or more acrylate moieties;
- and
- the ratio of the sugar alcohol units to the alkanedioic acid units in the polymer is 1 unit of sugar alcohol to at least 2 units of alkanedioic acid.
A polymer, wherein the backbone consists of alternating sugar alcohol and alkanedioic acid units, wherein:
- each sugar alcohol unit independently comprises at least four —O— moieties;
- each alkanedioic acid unit independently has the structure of —C(O)(CH2)xC(O)—, wherein x is an integer of between 1 to 20, inclusive, and each of the —(CH2)— unit is optionally and independently substituted;
- the ratio of the sugar alcohol units to the alkanedioic acid units in the polymer is 1 unit of sugar alcohol to at least 2 units of alkanedioic acid.
Dependencies are inferred from the claim text.