Method for treating cell degeneration using at least one molecule capable of inhibiting adhesion molecule expression and vascular endothelium actin fibre polymerization
AssigneeAisa Therapeutics
InventorPatrizia D'Alessio
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Abstract
The invention relates to the use of a molecule selected from the group which consists of geranyl acetate, geraniol, isomenthone, limonene or a mixture of at least two of the above, for preparing a drug for treating or preventing vascular endothelial cell senescence and subjacent tissue degeneration induced by repeated inflammatory episodes. Specifically, the drug is useful for treating vascular endothelial cell senescence and tissue degeneration induced by repeated inflammatory episodes resulting from the presence of cancer cells.
Claims11
A method for treating the senescence of vascular endothelial cells induced by repeated inflammatory episodes in an individual in need thereof, which comprises administering to an individual having senescence of vascular endothelial cells induced by repeated inflammatory episodes at least one plant-origin compound of terpene type, wherein said plant-origin terpene compound is selected from the group consisting of geranyl acetate, geraniol, isomenthone and limonene and said plant-origin compound of terpene type reverses the senescent phenotype of vascular endothelial cells and wherein said individual is selected by determining in a biological sample of an individual comprising vascular endothelial cells the expression level of the adhesion molecule ICAM-1 and wherein a patient is selected when ICAM-1 is overexpressed in vascular endothelial cells.
A method for treating the senescence of vascular endothelial cells induced by arthrosis in an individual in need thereof which comprises administering an individual having senescence of vascular endothelial cells induced by arthrosis at least one plant-origin compound of terpene type, wherein said plant-origin terpene compound is selected from the group consisting of geranyl acetate, geraniol, isomenthone and limonene and said plant-origin compound of terpene type reverses the senescent phenotype of vascular endothelial cells and wherein said individual is selected by determining in a biological sample of an individual comprising vascular endothelial cells the expression level of the adhesion molecule ICAM-1 and wherein a patient is selected when ICAM-1 is overexpressed in vascular endothelial cells.
Dependencies are inferred from the claim text.