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US 8,912,221 B2Granted
Biaryl amide derivatives
AssigneeHoffmann-La Roche Inc.
InventorsJohannes Aebi, Alfred Binggeli, Cornelia Hertel, Anish Ashok Konkar, Holger Kuehne, Bernd Kuhn, Hans P. Maerki, Haiyan Wang
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Abstract
The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and A are as described herein, compositions including the compounds and methods of using the compounds.
Claims5
A compound according to formula (I):
- wherein:
- R1 is isoxazolyl, optionally substituted with lower alkyl or alkoxy;
- R2 is selected from the group consisting of hydrogen, alkyl and cycloalkyl;
- R3 is selected from the group consisting of hydrogen, alkyl and cycloalkyl;
- R4 is selected from the group consisting of hydrogen, alkyl and cycloalkyl;
- R5 is selected from the group consisting of hydrogen, alkyl and cycloalkyl;
- or R4 and R5 together form a cycloalkyl with the carbon they are attached to;
- R6 is selected from the group consisting of hydrogen and halogen;
- R7 is hydrogen;
- R8 is alkyloxadiazolyl;
- R9 is selected from the group consisting of hydrogen and halogen;
- R10 is hydrogen;
- R11 is selected from the group consisting of hydrogen and halogen;
- R12 is hydrogen;
- R13 is selected from the group consisting of hydrogen and halogen;
- A is N;
- and
- wherein one of R4 and R5 is hydrogen and the other is alkyl,
- or a pharmaceutically acceptable salt thereof.
16 more elements
Dependencies are inferred from the claim text.