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US 8,912,215 B2Granted
Rapamycin composition
AssigneeEveron Biosciences, Inc.
InventorsGrzegorz Pietrzynski, Valery Alakhov, Kishore Patel
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Abstract
In one aspect, the present invention is directed to a dry, flowable and compressible rapamycin composition comprising a specific mixture of hydrophobic and hydrophilic poly(ethylene oxide)-polypropylene oxide)-poly(ethylene oxide) block copolymers. In other aspects, the present invention is directed to a method of making the composition.
Claims17
A dry, flowable and compressible composition comprising:
- a. a hydrophobic poly(ethylene oxide)-polypropylene oxide)-poly(ethylene oxide) block copolymer;
- b. a hydrophilic poly(ethylene oxide)-polypropylene oxide)-poly(ethylene oxide) block copolymer;
- and
- c. rapamycin.
1 more element
A process for preparing a dry, flowable and compressible rapamycin composition comprising the steps of:
- a. mixing a (i) a hydrophobic poly(ethylene oxide)-polypropylene oxide)-poly(ethylene oxide) block copolymer;
- (ii) a hydrophilic poly(ethylene oxide)-polypropylene oxide)-poly(ethylene oxide) block copolymer;
- and (iii) rapamycin;
- in an organic solvent to form an organic mixture;
- and
- b. drying the organic mixture.
3 more elements
Dependencies are inferred from the claim text.