Medicinal compositions comprising buprenorphine and naltrexone
AssigneeRB Pharmaceuticals Limited
InventorsChristopher Bourne Chapleo, Neil Hyde
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Abstract
An analgesic composition, in parenteral unit dosage form or in a unit dosage form suitable for delivery via the dermis or mucosa, comprises buprenorphine and an amount of naltrexone such that the ratio by weight of buprenorphine to naltrexone delivered to or reaching the plasma of a patient is in the range 100:1 to 5000:1. The analgesic action of the buprenorphine is potentiated by the low dose of naltrexone. Also provided are a method of treatment of pain and the use of buprenorphine and naltrexone for the manufacture of a medicament.
Claims9
An analgesic composition, in parenteral unit dosage form or in a unit dosage form suitable for delivery via the mucosa, the composition comprising buprenorphine and an amount of naltrexone such that the ratio by weight of buprenorphine to naltrexone delivered to, or reaching the plasma of, a patient is in the range 100:1 to 500:1, and wherein the amount of buprenorphine in the unit dosage form is from 10 μg to 1 mg, wherein the composition is an immediate release composition.
A method for the treatment of pain in a human patient, which method comprises the administration to a human patient, by a parenteral or mucosal route, of buprenorphine and naltrexone such that the ratio by weight of buprenorphine to naltrexone delivered to, or reaching the plasma of, said patient is in the range:
- 100:1 to 500:1.
Dependencies are inferred from the claim text.