Piperidinone carboxamide azaindane CGRP receptor antagonists
AssigneeMerck Sharp & Dohme Corp.
InventorsIan M. Bell, Mark E. Fraley, Steven N. Gallicchio, Anthony Ginnetti, Helen J. Mitchell, Daniel V. Paone, Donnette D. Staas, Cheng Wang, C. Blair Zartman
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Abstract
The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
Claims11
The compound
- or a pharmaceutically acceptable salt thereof.
The compound
- or a pharmaceutically acceptable salt thereof.
The compound
- or a pharmaceutically acceptable salt thereof.
The compound
- or a pharmaceutically acceptable salt thereof.
A compound selected from the following group:
- R1
- 3,3,3-trifluoropropyl
- 2-methylpropyl
- (2S)-3,3,3-trifluoro-2-hydroxypropyl
- cyclopropylmethyl
- [1-(trifluoromethyl)cyclopropyl]methyl
- 2,2-difluoroethyl
- [(1R)-2,2-difluorocyclopropyl]methyl
- [(1S)-2,2-difluorocyclopropyl]methyl
- or a pharmaceutically acceptable salt of any of the foregoing compounds.
The compound
Dependencies are inferred from the claim text.