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US 8,912,206 B2Granted
Pyrimidine ether derivatives and methods of use thereof
AssigneeMerck Sharp & Dohme Corp.
InventorsSanthosh Francis Neelamkavil, Andrew Stamford, Samuel Chackalamannil, William J. Greenlee
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Abstract
The present invention relates to Pyrimidine Ether Derivatives, compositions comprising a Pyrimidine Ether Derivative, and methods of using the Pyrimidine Ether Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a G-protein coupled receptor (GPCR) in a patient.
Claims10
A compound having the formula:
- wherein:
- Q is —C(O)O— or a bond;
- W is —C(O)—, —C(O)O— or —S(O)2—;
- Y is halo;
- R3 is alkyl, haloalkyl, cycloalkyl or -alkylene-O-alkyl;
- and
- R10 is cycloalkyl or heteroaryl, either of which can be substituted with an alkyl or halo group.
4 more elements
A compound having the structure:
- or a pharmaceutically acceptable salt thereof.
A compound which is:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.