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US 8,912,201 B2Granted
6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
AssigneeBoehringer Ingelheim International GmbH
InventorsNiklas Heine, Christian Eickmeier, Marco Ferrara, Riccardo Giovannini, Holger Rosenbrock, Gerhard Schaenzle
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Abstract
The invention relates to novel 6-cycloalkyl-pyrazolopyrimidinones according to formula (I) wherein R1, R2, D, m and n are as defined herein. The invention also relates to medicaments comprising these compounds and methods of using these compounds in the treatment of diseases and conditions, particularly diseases or conditions concerning deficits in perception, concentration, learning or memory.
Claims25
A compound of formula (I)
- wherein
- R1 is a 5 or 6 membered heteroaryl-group whereby 1, 2, 3 or 4 of the ring atoms are heteroatoms that are selected independently of each other from N, O or S,
- whereby said 5 or 6 membered aromatic heteroaryl-group optionally may be substituted by 1, 2, 3 or 4 substituents, whereby said substituents may be selected independently of one another from the group consisting of fluorine, chlorine, bromine, HO—, NC—, F3C—, HF2C—, FH2C—, methyl, H2N— and (CH3)2N—;
- R2 is selected from the group consisting of fluorine, NC—, F3C—, HF2C—, FH2C— and methyl;
- D is selected from the group consisting of cyclopentyl, cyclohexyl, tetrahydrofuranyl, tetrahydropyranyl, 2-, 3- and 4-pyridyl,
- whereby cyclopentyl and cyclohexyl optionally may be substituted by 1 or 2 substituents, whereby said substituents may be selected independently of one another from the group consisting of fluorine, NC—, F3C—, HF2C— and FH2C—;
- whereby tetrahydrofuranyl and tetrahydropyranyl optionally may be substituted by 1 or 2 substituents, whereby said substituents may be selected independently of one another from the group consisting of fluorine, NC—, F3C—, HF2C— and FH2C—;
- whereby pyridyl optionally may be substituted by 1, 2, 3 or 4 substituents, whereby said substituents may be selected independently of one another from the group consisting of fluorine, chlorine, bromine, NC—, F3C—, HF2C—, FH2C—, F3C—CH2—, C1-6-alkyl- and C3-7-cycloalkyl,
- m is selected from 1 or 2;
- n is selected from 0, 1 or 2,
- whereby if n=2, two R2 groups are selected independently of one another;
- or a pharmaceutically acceptable salt thereof;
- with the proviso that the compound is not
- be it in the form of any possible stereoisomer or a mixture of all or some thereof.
11 more elements
Dependencies are inferred from the claim text.