Allosteric protein kinase modulators

A compound of formula I:

• wherein,
• Y is C;
• W is C;
• X1 taken together with X3 forms a double bond between Y and W;
• X2 is Q2;
• X3 taken together with X1 forms a double bond between W and Y;
• Q2 H;
• Q1 is COOH or COOR1;
• P is absent and Q1 is bonded to Y by a single bond;
• V is CH2;
• U is CH2;
• R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are at each occurrence in the compound of formula I C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C3-6cycloalkenyl, optionally substituted heteroaryl or optionally substituted aryl;
• Ar2 is a phenyl ring, a naphthyl ring, or an indenyl ring carrying 0-4 substituents R12;
• Ar1 is an aryl or a heteroaryl group selected from the group consisting of phenyl, naphthyl, indolyl, benzofuranyl, benzothiophenyl, isoindolyl, indazolyl, benzo[d]isothiazolyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, isoquinolinyl, quinolinyl, phthalazinyl, quinoxalinyl, quinazolinyl, cinnolinyl, and naphthoimidazolyl, wherein the aryl group or the heteroaryl group carry 1-4 substituents R12, and wherein any stable S or N ring atom of said heteroaryl group may be substituted with oxo;
• R12 is at each occurrence in the compound of formula I selected from the group consisting of hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C3-6cycloalkenyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, optionally substituted aryl, —F, —Cl, —Br, —I, —CF3, —Z—OR13, —Z—NO2, —Z—NR13OOR14, —Z—NR13R14, —Z—SR13, —Z—COOR13, —Z—CONR13R14, —Z—C(O)SR13, —Z—C(O)NR13OR14, —Z—CN, —Z—COR13, —Z—COOCH2C(O) R13, —Z—COOCH2C(O)NR13R14, —Z—SOR13, —Z—SO2R13, —Z—SO2NR13R14, —Z—P(O)(OR13)OR14 and —Z-tetrazol-5-yl;
• Z is a single bond or a bivalent spacer group;
• R13 and R14 are at each occurrence in the compound of formula I independently selected from the group consisting of hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C3-6cycloalkenyl, optionally substituted heteroaryl and optionally substituted aryl, or
• a pharmaceutically acceptable salt, solvate, diastereomer, enantiomer, tautomer or racemate thereof.