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US 8,912,164 B2Granted
Re-epithelializing pharmaceutical compositions comprising xanthan gum
AssigneeSIFI S.p.A.
InventorsMaria Grazia Mazzone, Grazia Paladino, Clara Marino, Ornella Peri, Vincenzo Enea
Life of this patent
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Abstract
The present invention relates to a pharmaceutical formulation comprising xanthan gum as a re-epithelializing active principle optionally mixed with hyaluronic acid. The composition speeds up and improves advantageously the formation of newly grown epithelium.
Claims2
A pharmaceutical re-epithelializing composition consisting of:
- 0.15 weight % hyaluronic acid sodium salt as active principle,
- 1.0 weight % xanthan gum as active principle,
- 0.35 weight % sodium chloride as isotonic agent,
- 0.15 weight % potassium chloride as isotonic agent,
- 0.012 weight % magnesium chloride.6H2O as isotonic agent,
- 0.0084 weight % calcium chloride.2H2O as isotonic agent,
- 0.089 weight % sodium phosphate dibasic.12H2O as buffer,
- 0.0069 weight % sodium phosphate monobasic.H2O as buffer,
- 0.059 weight % sodium citrate.2H2O as buffer and antioxidant,
- 1.0 weight % glycerol as isotonic agent, and
- purified water as solvent,
- wherein the composition is effective for re-epithelialization when applied to epithelium;
- and
- the xanthan gum and isotonic agent provide recovery of the structure and viscosity of the composition between blinks resulting in increased time of corneal contact.
11 more elements
A pharmaceutical re-epithelializing composition consisting of:
- 0.455 weight % netilmicin sulfate as active principle,
- 0.3 weight % netilmicin base,
- 0.15 weight % sodium hyaluronate as active principle,
- 1.0 weight % xanthan gum as active principle,
- 0.5 weight % of sodium phosphate dibasic dodecahydrate as buffer,
- 0.1465 weight % sodium phosphate monobasic monohydrate as buffer,
- 2.1 weight % sodium citrate dihydrate as buffer and antioxidant, and
- purified water as solvent,
- wherein the composition is effective for re-epithelialization when applied to epithelium;
- and
- xanthan gum and salt provide recovery of the structure and viscosity of the composition between blinks resulting in increased time of corneal contact.
8 more elements
Dependencies are inferred from the claim text.