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AssigneesNational Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), NIH Division of Extramural Inventions and Technology Resources (DEITR)
InventorsVijaya Iragavarapu-Charyulu, Ramon Garcia-Areas, Stephania Libreros
Estimating the term…
Methods, assays, and kits for determining a cancer's (e.g., breast cancer) metastatic potential and tumor aggressiveness in a subject (e.g., a human patient) and for measuring a subject's response to cancer therapy involve analyzing expression of Sema7A in a biological sample from the subject, and correlating increased expression of Sema7A in the biological sample compared to a control sample with metastatic potential of the cancer, wherein the expression of Sema7A is linearly proportional to the metastatic potential of the cancer in the subject. These methods, kits and assays provide for individualized diagnosis and treatment options for cancer (e.g., breast cancer) patients. They can be used independently, or can be combined with additional diagnostic tests and/or prognostic methods. Compositions, kits and methods for treating a subject having cancer (e.g., breast cancer) include administering a composition for inhibiting Sema7A expression or activity to the subject.
A method of inhibiting growth of breast cancer cells in a subject, comprising administering to the subject a composition comprising a therapeutically effective amount of a Sema7A inhibitor that is an RNA molecule that reduces or prevents expression of Sema7A for inhibiting growth of breast cancer cells in the subject.
Dependencies are inferred from the claim text.