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US 8,912,149 B1Granted
Glycosaminoglycan mimetics
AssigneeCalifornia Institute of Technology
InventorsManish Rawat, Linda Hsieh-Wilson
Life of this patent
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Abstract
The present invention provides composition comprising one or more glycosaminoglycan mimetics and uses thereof. The subject glycosaminoglycan mimetics are particularly useful for treatment of neuronal injuries including without limitation spinal cord injuries.
Claims32
A sulfated glycosaminoglycan mimetic polymer having a plurality of repeating subunits, wherein an individual repeating subunit of said repeating subunits is a saccharide covalently linked to a backbone, wherein the number of repeating subunits in said polymer is m, and wherein the sulfated glycosaminoglycan mimetic polymer is of a formula:
- or
- or a pharmaceutically acceptable salt or ester thereof;
- wherein R1, R2, R3, and R4 are each independently selected from the group consisting of hydroxyl, sulfate, and phosphate;
- one or more of R1, R2, R3, and R4 is a sulfate;
- R6 is selected from the group consisting of hydrogen, sulfite and acetyl;
- n is 1 or greater;
- wherein n1 is between 1 and 25, n2 is between 1 and 10, n3 is between 1 and 10;
- and m is 2 or greater.
5 more elements
Dependencies are inferred from the claim text.