Methods of treating a disease or condition associated with abnormal angiogenesis

A method for treating a disease or symptom associated with an angiogenic disorder, comprising administering to the subject a therapeutically effective amount of an AA targeting compound, salt, of the formula:

• (SEQ ID NO:
• 43)
• R1-Q1 (AcK)2 Y3 Q4 P5 L6 D7 E8 (AcK)9 D10 K11 T12 L13 Y14
• D15 Q16 F17 M18 L19 Q20 Q21 G22-R2
• wherein
• R1 is CH3, C(O)CH3,C(O)CH3, C(O)CH2CH3, C(O)CH2CH2CH3, C(O)CH(CH3)CH3, C(O)CH2CH2CH2CH3, C(O)CH(CH3)CH2CH3, C(O)C6H5, C(O)CH2CH2(CH2CH2O)1-5Me, dichlorobenzoyl (DCB), difluorobenzoyl (DFB), pyridinyl carboxlate (PyC) or amido-2-PEG, an amino protecting group, a lipid fatty acid group or a carbohydrate;
• and
• R2 is OH, NH2, NH(CH3), NHCH2CH3, NHCH2CH2CH3, NHCH(CH3)CH3, NHCH2CH2CH2CH3, NHCH(CH3)CH2CH3, NHC6H5, NHCH2CH2OCH3, NHOCH3, NHOCH2CH3, a carboxy protecting group, a lipid fatty acid group or a carbohydrate,
• wherein the angiogenic disorder is selected from the group consisting of angiogenesis of the eye associated with infection or surgical intervention, macular degeneration, diabetic retinopathy, carcinomas of the breast, colon, rectum, lung, oropharynx, hypopharynx, esophagus, stomach, pancreas, liver, gallbladder and bile ducts, small intestine, urinary tract, female genital tract, male genital tract, endocrine glands, and skin;
• hemangiomas;
• melanomas;
• sarcomas;
• tumors of the brain, nerves, eyes, and meninges;
• leukemia;
• and lymphoma.