Vaccine composition for prophylaxis and/or therapy of Alzheimer's disease
AssigneeHokko Chemical Industry Co., Ltd.
InventorsTeruhiko Terakawa, Hisakazu Hasegawa, Yasushi Shimada, Atsushi Takahashi, Takeshi Kawarabayashi, Mikio Shoji
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Abstract
A vaccine composition for prophylaxis and/or therapy of Alzheimer's disease, which comprises a fusion protein prepared by inserting a single or tandemly repeated multiple copies of amyloid β antigenic peptide having 5 to 15 continuous amino acid residues derived from the N-terminus of amyloid β peptide into a wild type seed storage protein.
Claims16
A vaccine composition for decreasing amyloid plaque formation and/or therapy of Alzheimer's disease, which comprises a fusion protein prepared by inserting tandemly repeated 2 to 5 copies of amyloid β antigenic peptide consisting of the amino acid sequence of SEQ ID NO:3 into a wild type seed storage protein, wherein said seed storage protein is AlaBlb subunit of so bean 11S globulin, and said tandemly repeated 2 to 5 copies of amyloid β antigenic peptide have been inserted into a variable region encoding the amino acid sequence corresponding to amino acid positions 198-216 of SEQ ID NO:2.
A method for decreasing amyloid plaque formation and/or treating Alzheimer's disease, said method comprising the step of administering a vaccine composition to an animal which has amyloid plaques in its brain, wherein said vaccine composition comprises a fusion protein prepared by inserting tandemly repeated 2 to 5 copies of amyloid β antigenic peptide consisting of the amino acid sequence of SEQ ID NO:3 into a wild type seed storage protein, wherein said seed storage protein is A1aB1b subunit of soybean 11S globulin, and said tandemly repeated 2 to 5 copies of amyloid β antigenic peptide have been inserted into a variable region encoding the amino acid sequence corresponding to amino acid positions 198-216 of SEQ ID NO:2.
A vaccine composition for decreasing amyloid plaque formation and/or therapy of Alzheimer's disease, which comprises a fusion protein comprising a) tandemly repeated 2 to 5 copies of amyloid β antigenic peptide consisting of the amino acid sequence of SEQ ID NO:3;
- and b) a wild type seed storage protein, wherein said seed storage protein is A1aB1b subunit of soybean 11S globulin, and said tandemly repeated 2 to 5 copies of amyloid βantigenic peptide have been inserted into a variable region encoding the amino acid sequence corresponding to amino acid positions 198-216 of SEQ ID NO:2.
Dependencies are inferred from the claim text.