Method for treating stroke via administration of NEP1-40 and inosine
AssigneeChildren's Medical Center Corporation
InventorLarry I. Benowitz
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Abstract
Disclosed herein is a method for stimulating axonal outgrowth of central nervous system (CNS) neurons comprising contacting the CNS neurons with an effective amount of NEP1-40 and inosine, to thereby stimulate axonal outgrowth. The method may further comprise contacting the CNS neurons with a cAMP modulator that increases the concentration of intracellular cAMP. Also disclosed is a method for treating a neurological disorder selected from the group consisting of traumatic brain injury, stroke, spinal cord injury, optic neuropathy, retinal nerve damage and optic nerve damage, in a patient in need thereof comprising administering an effective amount of NEP1-40 and inosine to the patient.
Claims6
A method for stimulating axonal outgrowth of mammalian central nervous system (CNS) neurons damaged by stroke comprising contacting the CNS neurons with an effective amount of NEP1-40 and inosine, to thereby stimulate axonal outgrowth.
A method for treating stroke in a patient in need thereof comprising administering an effective amount of NEP1-40 and inosine to the patient, to thereby contact and stimulate axonal outgrowth of central nervous system (CNS) neurons damaged by stroke, to thereby treat the stroke.
Dependencies are inferred from the claim text.