Methods and compositions related to clot-binding compounds
AssigneeSanford-Burnham Medical Research Institute
InventorsErkki Ruoslahti, Lilach Agemy, Venkata Ramana Kotamraju
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Abstract
Disclosed are compositions and methods related to clot-binding compounds. For example, disclosed are compositions comprising a surface molecule and at least one modified clot-binding compound. The modified clot-binding compound can selectively bind to clotted plasma protein, wherein the composition causes clotting and amplifies the accumulation of the composition in tumors. The modified clot-binding compound can enhance the clotting in tumors compared to its unmodified derivative. The disclosed targeting is useful for treatment of cancer and other diseases and disorders.
Claims56
A composition comprising a surface molecule selected from the group consisting of an iron oxide nanoworm, an iron oxide nanoparticle, an albumin nanoparticle, a liposome, a microparticle, and a fluorocarbon microbubble and at least one clot-binding compound, wherein the clot-binding compound comprises an amino acid sequence selected from the group consisting of C(NMe)REKA (SEQ ID NO:8), CR(NMe)EKA (SEQ ID NO:9), CR(CMe)EKA (SEQ ID NO:10), CRE(NMe)KA (SEQ ID NO:11), CRE(CMe)KA (SEQ ID NO:12), and CR(NMe)E(NMe)KA (SEQ ID NO:
- 13) and selectively binds to clotted plasma protein, wherein the composition causes clotting and amplifies the accumulation of the composition in tumors, wherein the clot-binding compound enhances the clotting in tumors compared to its unmodified derivative.
Dependencies are inferred from the claim text.