Methods of forming and using a solid-phase support

A method of making a substrate for performing a chemical synthesis reaction, the method comprising the steps of:

• providing a dispensing plate comprising a plurality of recesses, wherein the plurality of recesses have one or more particles disposed therein;
• aligning a plurality of reaction vessels with the plurality of recesses, such that each reaction vessel is aligned with a different recess, wherein the plurality of reaction vessels comprises a multiwell substrate comprising a plurality of wells;
• dispensing particles from the recesses to the plurality of reaction vessels aligned with the plurality of recesses, the particles being functionalized for covalent attachment of a building block of a synthetic reaction;
• permanently embedding the particles in the plurality of reaction vessels;
• and
• adding the building block to the particles in a reaction vessel of the plurality of reaction vessels.