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US 8,912,117 B2Granted
Cellulose gel for purification of immunoglobulin
AssigneeJnc Corporation
InventorsYoshihiro Matsumoto, Yasuto Umeda, Shigeyuki Aoyama, Masami Todokoro
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AssigneeJnc Corporation
InventorsYoshihiro Matsumoto, Yasuto Umeda, Shigeyuki Aoyama, Masami Todokoro
Estimating the term…
The present invention provides a chromatography packing material having improved flow rate characteristics and adsorption characteristics. In particular, the present invention provides a chromatography packing material suitable for separation and purification of immunoglobulin in the manufacture of antibody preparations. A porous cellulose gel, which is made by adding polysaccharides having a limiting viscosity of 0.21 to 0.90 dL/g to porous cellulose particles, the dry weight per unit volume of the porous cellulose gel being 1.06 to 1.40 times the dry weight per unit volume of the porous cellulose particles, is used. By adding a predetermined amount of polysaccharides having a predetermined limiting viscosity to porous cellulose particles, flow rate characteristics and adsorption characteristics can be improved.
A porous cellulose gel, which is made by adding polysaccharides having a limiting viscosity of 0.21 to 0.90 dL/g to porous cellulose particles, the dry weight per unit volume of the porous cellulose gel being 1.06 to 1.40 times the dry weight per unit volume of the porous cellulose particles.
A method for producing a chromatography packing material, comprising the step of adding a ligand to a porous cellulose gel, which is made by adding polysaccharides having a limiting viscosity of 0.21 to 0.90 dL/g to porous cellulose particles, the dry eight per unit volume of the porous cellulose gel being 1.06 to 1.40 times the dry weight per unit volume of the porous cellulose particles.
Dependencies are inferred from the claim text.