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US 8,912,011 B2Granted
Antibodies to sulfated carbohydrates
AssigneeCalifornia Institute of Technology
InventorsSarah E. Tully, Linda C. Hsieh-Wilson
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Abstract
The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to chondroitin sulfate, particularly CS-A, CS-C and CS-E tetrasaccharides. The present invention also relates to methods of making anti-CS antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment.
Claims4
A method of generating an antibody comprising:
- (a) synthesizing a population of chondroitin sulfates, wherein individual members of said population are oligosaccharides made of one subunit selected from the group consisting of:
- (b) inoculating a host animal with said population of chondroitin sulfates, wherein said inoculation induces in said host animal the production of one or more antibodies that selectively bind to said chondroitin sulfates;
- and
- (c) selecting from said one or more antibodies an antibody that selectively binds to an epitope recognized by antibody 2D11-2A10.
1 more element
Dependencies are inferred from the claim text.