Electrospun scaffolds and methods of generating and using same
AssigneeTechnion Research & Development Foundation Limited
InventorsSamer Srouji, Eyal Zussman, Erella Livne
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Abstract
A porous scaffold is disclosed, the porous scaffold comprising electrospun polymeric nanofibers, wherein an average diameter of a pore of the porous scaffold is about 300 μm is disclosed. An average diameter of the polymeric nanofibers ranges from about 100 to 400 nm. The scaffold may comprise a plurality of particles, the particles being greater than about 1 μm in diameter. Methods of fabricating scaffolds, methods for generating tissue and methods of using scaffolds for tissue reconstruction are also disclosed.
Claims18
A non-woven electrospun scaffold comprising polymeric nanofibers and a plurality of osteoconductive particles comprising hydroxylapatite (HA), wherein an average diameter of said polymeric nanofibers ranges from about 100 to 400 nm and whereas said osteoconductive particles are greater than 1 μm in diameter, wherein said polymeric nanofibers and a plurality of osteoconductive particles are concomitantly dispensed from two separate dispensers, and wherein said osteoconductive particles are situated between said electrospun polymeric nanofibers.
Dependencies are inferred from the claim text.