Method for neutralization of antibiotics in a culture medium
AssigneeBiomerieux
InventorDouglas Lovern
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Abstract
The present invention is directed to a method and means for the neutralization, binding, and/or inactivation of antimicrobials in a test sample. The invention is also directed to a method of detecting the presence of one or more microorganisms in a test sample by culturing the test sample in a culture media comprising one or more primary amine-containing compounds.
Claims7
A method for the neutralization and/or inactivation of an antimicrobial in a culture medium, the method comprising adding one or more non-thiol containing primary amines to said culture medium capable of supporting growth of microorganisms, wherein said one or more non-thiol containing primary amines are present in an amount effective for neutralization and/or inactivation of any antimicrobials that may be present in said culture medium, and wherein said one or more non-thiol containing primary amines are selected from the group consisting of methylamine, ethanolamine, trisamine, propylamine, 2-aminoheptane, 2 amino-2-methyl-1,3 propanediol, 2-amino-2-methyl-1-propanol, n-amylamine, benzylamine, 1,4-butanediamine, n-butylamine, cyclohexylamine, ethylamine, ethylenediamine, α-methylbenzylamine, phenethylamine, isopropylamine, butylamine, sec-butylamine, iso-butylamine, and tris(hydroxymethyl)aminomethane.
Dependencies are inferred from the claim text.