Method for identifying idiopathic pneumonia progression by measuring the level of mannose-binding protein C
AssigneeCase Western Reserve University
InventorsMark Chance, Kenneth Cooke, Daniela Schlatzer
Life of this patent
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Abstract
A method for characterizing the risk a subject will develop an autoimmune and/or alloimmune disease following tissue transplant includes obtaining a biological sample from the subject, wherein the subject has received the tissue transplant determining in the biological sample a level of at least one protein selected from Tables 1-4, comparing the measured level of the at least one protein to a control value, and characterizing a subject as at greater risk of developing an autoimmune disease and/or alloimmune disease if the level of at least one protein determined is increased or decreased compared to the control value.
Claims3
A method for identifying idiopathic pneumonia syndrome (IPS) progression in a subject following allogeneic hematopoietic stem cell transplantation, the method comprising:
- obtaining a biological sample from the subject, wherein the biological sample comprises a sample of blood, plasma, serum, or bronchoalveolar lavage fluid, wherein the subject has received the allogeneic hematopoietic stem cell transplantation;
- and
- determining in the biological sample a level of Mannose-binding protein C;
- comparing the measured level of Mannose-binding protein C to a control level prior to transplantation;
- and
- identifying the IPS as progressing if the level of Mannose-binding protein C determined is decreased at least about 5% compared to the control level.
Dependencies are inferred from the claim text.