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US 8,911,956 B2Granted
Methods of use for an immunoassay detecting fragment Ba
AssigneeQuidel Corporation
InventorsNikol Lee De Forest, John Tamerius, Noah Nasser, Patrick Sexton
Life of this patent
Estimating the term…
Abstract
Methods, compositions and kits for detecting the complement Factor B cleavage product Ba in a biological sample are described. These methods, compositions and kits are useful in convenient, reliable and early diagnosis of or ruling out pre-eclampsia in a pregnant human subject.
Claims8
A method for ruling out pre-eclampsia in a pregnant human subject, comprising:
- contacting a sample of a body fluid obtained at a time period between 8 and 42 weeks of pregnancy from the subject with an antibody to a neo-epitope on the Ba fragment (Ba) of Factor B, said antibody does not substantially recognize Factor B or the Bb fragment (Bb) of Factor B;
- detecting whether the antibody binds to the neo-epitope on Ba in the sample;
- and
- identifying as “ruled-out” those pregnant human subjects for which no binding is detected.
1 more element
Dependencies are inferred from the claim text.