TDF-related compounds and analogs thereof, analogs and bioactive fragments
AssigneeThrasos Innovation, Inc.
InventorsWilliam D. Carlson, Peter C. Keck, Dattatreyamurty Bosukonda, Philippe Bey
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Abstract
The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
Claims17
A purified polypeptide comprising the amino acid sequence set forth in SEQ ID NO:335.
A purified polypeptide comprising the amino acid sequence set forth in SEQ ID NO:335, wherein each cysteine residue is replaced with an amino acid having a side chain containing a hydroxyl, thiol, amine, carboxylic acid or sulfonic acid moiety.
A purified polypeptide consisting of the amino acid sequence set forth in SEQ ID NO:335.
A purified polypeptide comprising the amino acid sequence set forth in SEQ ID NO:335, wherein the purified polypeptide is linear or cyclic.
A purified polypeptide comprising the amino acid sequence set forth in SEQ ID NO:335, wherein the purified polypeptide is a cyclized disulfide polypeptide.
Dependencies are inferred from the claim text.