Muscadine compositions with improved anti-oxidant activity

A method of inhibiting free radical formation and/or free radical activity, comprising administering to a subject an amount of a composition comprising

• a muscadine (Vitis rotundifolia) pomace solvent extract comprising a mixture of a bronze muscadine pomace extract and a purple muscadine extract, wherein a) the bronze muscadine pomace extract and the purple muscadine pomace extract are liquid solvent extracts that are filtered and fermented extracts, and b) the ratio of bronze muscadine pomace extract to purple muscadine pomace extract ranges from 0.1 to 10 (weight to weight) and has a polyphenol content of at least 2%;
• and
• resveratrol from a source other than muscadine with a minimum purity of at least 5% trans-resveratrol;
• wherein a ratio of muscadine pomace extract polyphenols to trans-resveratrol is in the range of 0.1/1 to 10/1 (weight to weight),
• wherein the composition has antioxidant activity and is in an amount sufficient to inhibit free radical formation and/or free radical activity.

A method of improving skin quality, comprising administering to a subject an amount of a composition comprising

• a muscadine (Vitis rotundifolia) pomace solvent extract comprising a liquid bronze muscadine pomace extract combined with a liquid purple muscadine pomace extract to produce a liquid muscadine pomace extract, wherein a) the bronze muscadine pomace extract and the purple muscadine pomace extract are solvent extracts;
• b) the mixture of bronze muscadine pomace extract and purple muscadine pomace extract promotes solubility of ellagic acid in the muscadine pomace extract;
• c) the bronze muscadine pomace extract and the purple muscadine pomace extract are filtered and fermented extracts;
• and d) the muscadine pomace solvent extract has a polyphenol content of at least 2%;
• and
• resveratrol from a source other than muscadine with a minimum purity of at least 5% trans-resveratrol,
• wherein a ratio of muscadine pomace extract polyphenols to trans-resveratrol is in the range of 0.1/1 to 10/1 (weight to weight), wherein the composition has antioxidant activity and is in an amount sufficient to improve skin quality.

A method of improving skin quality, comprising administering to a subject an amount of a composition comprising

• a muscadine (Vitis rotundifolia) pomace solvent extract comprising a mixture of a bronze muscadine pomace extract and a purple muscadine extract, wherein a) the bronze muscadine pomace extract and the purple muscadine pomace extract are liquid solvent extracts that are filtered and fermented extracts, and b) the ratio of bronze muscadine pomace extract to purple muscadine pomace extract ranges from 0.1 to 10 (weight to weight) and has a polyphenol content of at least 2%;
• and
• resveratrol from a source other than muscadine with a minimum purity of at least 5% trans-resveratrol;
• wherein a ratio of muscadine pomace extract polyphenols to trans-resveratrol is in the range of 0.1/1 to 10/1 (weight to weight),
• wherein the composition has antioxidant activity and is in an amount sufficient to improve skin quality.