Multiparticulate L-menthol formulations and related methods
AssigneeZx Pharma, LLC
InventorsSyed Shah, Fred Hassan, Daniel Hassan, Sarah Hassan
Life of this patent
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Abstract
An L-menthol-containing multiparticulate formulation includes a plurality of individual enteric coated cores containing L-menthol from an at least 80% pure L-menthol source. The enteric coated cores are effective to release at least about 35% of the L-menthol within about two hours, and at least about 80% of the L-menthol within about eight hours after being placed in an environment having a pH of 5 to 8. The L-menthol multiparticulate formulation can be used to treat gastrointestinal disorders.
Claims24
A multiparticulate formulation comprising a plurality of individual enteric coated cores containing L-menthol from an at least 80% pure L-menthol source and having a continuous proteinaceous subcoating layer covering the individual cores and separating the individual cores from their respective enteric coatings, the individual enteric coated cores being effective to release at least about 35% of the L-menthol within about two hours and at least about 80% of the L-menthol within about eight hours after being placed in an environment having a pH of between 5 to 8.
A method of treating a gastrointestinal disorder in a subject, the method comprising administering orally to a subject in need thereof a multiparticulate formulation comprising a plurality of individual enteric coated cores containing L-menthol from an at least 80% pure L-menthol source and having a continuous proteinaceous subcoating layer covering the individual cores and separating the individual cores from their respective enteric coatings, the individual enteric coated cores being effective to release at least about 35% of the L-menthol within about two hours, and at least about 80% of the L-menthol within about eight hours after being placed in an environment having a pH of 5 to 8.
Dependencies are inferred from the claim text.