Pharmaceutical composition of tacrolimus

Minicapsules, wherein the minicapsules have a core composition that comprises tacrolimus and the minicapsules are seamless minicapsules obtainable by formulating tacrolimus as a solubilised formulation and encapsulating the solubilised formulation with a gelling agent, wherein the solubilised formulation comprises tacrolimus in combination with a pharmaceutically acceptable carrier that comprises a hydrophobic liquid and wherein the solubilised formulation is encapsulated by ejecting it through a nozzle having a single orifice in a mixed suspension which further comprises a solution comprising the gelling agent as well as the solubilised tacrolimus formulation, the ejected suspension forming into a spherical form and falling into a cooling air flow or a cooling or hardening solution where the gelling agent becomes gelled.

An oral tacrolimus composition comprising minicapsules having a core composition that comprises a hydrophobic liquid comprising tacrolimus in a solubilised liquid form, the minicapsules being seamless minicapsules and having a release profile to release the solubilised in the small intestine, the ileum and/or the colon, the minicapsules comprising a gelled state of a suspension that is a mixture of a solution comprising a gelling agent and of the hydrophobic liquid comprising tacrolimus, the gelling agent encapsulating the hydrophobic liquid comprising tacrolimus.