Crosslinked silane coating for medical devices
AssigneeCordis Corporation
InventorJonathon Z. Zhao
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Abstract
Coatings are provided in which surfaces may be activated by covalently bonding a combination of silane derivatives (A) to the metal surface, covalently bonding a lactone polymer (B) to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester (C) on the bonded lactone polymer. Biologically active agents or therapeutic compounds may be deposited with any of the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents.
Claims17
A composition comprising crosslinked silane derivatives linked to a surface of a medical device having at least two functional terminals comprising an epoxide group and a sulfhydryl group.
A composition for coating a surface prepared by a method comprising the steps of:
- activating the surface of a medical device to create a linkage;
- applying a silane derivative having a sulfhydryl group and a epoxide group to the activated surface;
- and
- oxidizing the sulfhydrl group to form sulfonic acid.
Dependencies are inferred from the claim text.