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US 8,911,762 B2Granted
Polylactic acid/calcium sulfate scaffold
AssigneeTaipei Medical University
InventorsWei-Chung Yang, Jen-Chang Yang, Duen-Jeng Wang, Sheng-Yang Lee, Yan-Chih Chen
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Abstract
The invention relates to a method of preparing a composite or porous composite used as a biodegradable scaffold, the composite prepared therefrom and the use of the composite. In particular, the composite is a calcium sulfate-polylactic acid composite or porous composite and the composite can be especially used as an in situ pore forming scaffold.
Claims6
A process for preparing a porous composite comprising calcium sulfate and polylactic acid, which consists of the following steps:
- (a) dehydrating calcium sulfate selected from calcium sulfate dihydrate, calcium sulfate alpha-hemihydrate or calcium sulfate beta-hemihydrate calcium or the mixture thereof to obtain calcium sulfate anhydrate;
- (b) melting polylactic acid at a high temperature and mixing the melted polylactic acid with calcium sulfate anhydrate to form a calcium-polylactic acid composite;
- and
- (c) particulate-leaching the calcium-polylactic acid composite to form a porous composite with interconnected pores;
- wherein the ratio of polylactic acid to calcium sulfate ranges from about 75%-65% (w/w) to about 25%-35% (w/w) and the pore size of the interconnected pores ranges from 100 to 500 μm.
2 more elements
Dependencies are inferred from the claim text.