Compositions for nasal delivery
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsElka Touitou, Biana Godin, Shaher Duchi
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Abstract
The present invention concerns a method of administering at least one active pharmaceutical agent to a patient in need thereof, which method comprises the intranasal administration of a composition comprising a therapeutically effective amount of this agent, phospholipids, one or more C2-C4 alcohols and water, wherein the concentrations of the phospholipids and the one or more alcohols in the composition are in the ranges of 0.2 to 10% and 12 to 30% by weight, respectively, with the water content of said composition being not less than 30% by weight, the phospholipids forming vesicles in said composition. Further are disclosed pharmaceutical compositions and combinations suitable for intranasal delivery.
Claims40
A method for the systemic administration of at least one active pharmaceutical agent, other than a nucleic acid, to a mammal, which method comprises administering to the mucous membranes of the nasal passage or nasal cavity of a mammal in need of the systemic administration of said agent, a composition comprising a therapeutically effective amount of said agent, phospholipids, one or more C2-C4 alcohols and water, wherein the concentrations of said phospholipids and said one or more alcohols in said composition are in the ranges of 0.2 to 10% and 12 to 30% by weight, respectively, with the water content of said composition being not less than 30% by weight, said phospholipids forming vesicles in said composition.
Dependencies are inferred from the claim text.