Cholera toxin chimera and its use as a staph vaccine
AssigneeBoise State University
InventorJuliette Tinker
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Abstract
The present invention relates to chimeric protein vaccines and methods of use thereof in the treatment of Staphylococcus aureus. One embodiment of the present invention provides a method of generating an immune response in a mammal, that includes administering to the mammal, a composition having a chimeric protein having at least one of: a portion of a cholera toxin, a portion of a heat-labile toxin, and a portion of a shiga toxin; and an antigen having at least one of: an antigenic material from S. aureus and an antigenic material from a S. aureus-specific polypeptide.
Claims7
A method of generating an immune response to Staphylococcus aureus in a mammal comprising administering to the mammal a composition comprising a chimeric protein comprising a cholera toxin A2 having the amino acid sequence of SEQ ID NO:
- 2 or an amino acid sequence that is at least 90% identical to SEQ ID NO:
- 2, a cholera toxin B having the amino acid sequence of SEQ ID NO:
- 3 or an amino acid sequence that is at least 90% identical to SEQ ID NO:
- 3, and an isolated Staphylococcus aureus-specific clumping factor A (ClfA) polypeptide consisting of amino acid residues 24-300 as set forth within the amino acid sequence of SEQ ID NO:
- 24.
Dependencies are inferred from the claim text.