HSV-1 and HSV-2 vaccines and methods of use thereof
AssigneeThe Trustees of the University of Pennsylvania
InventorsHarvey M. Friedman, Elizabeth E. Brittle, Fushan Wang
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Abstract
This invention provides methods of treating, suppressing, inhibiting, reducing an incidence, reducing the pathogenesis of, ameliorating the symptoms of, or ameliorating the secondary symptoms of a primary or recurring Herpes Simplex Virus (HSV) infection, or prolonging the latency to a relapse of an HSV infection, and disorders and symptoms associated with same and inducing an anti-HSV immune response in a subject comprising the step of contacting the subject with a composition comprising a mutant HSV strain comprising an inactivating mutation in a Us8 gene, followed by a second contacting with the composition.
Claims15
A method of suppressing a recurrent Herpes Simplex Virus (HSV) infection in a subject comprising the steps of:
- a) administering a composition comprising a mutant HSV-2 strain to said subject, wherein said mutant HSV-2 strain consists of a single inactivating mutation, wherein said inactivating mutation consists of the deletion of base pairs (bp) 369-1479 of SEQ ID NO:
- 7, and
- b) following step a) a second administration of said composition comprising said mutant HSV-2 strain is performed.
Dependencies are inferred from the claim text.