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AssigneeToray Industries, Inc.
InventorsTakanori Saito, Fumiyoshi Okano, Shinichi Kobayashi
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According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody or a fragment thereof as an active ingredient having immunological reactivity with a partial polypeptide of CAPRIN-1, which is represented by any of even-numbered sequences of SEQ ID NOS: 2 to 30, wherein the polypeptide has the amino acid sequence represented by SEQ ID NO: 37 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence represented by SEQ ID NO: 37.
A method for treating and/or preventing recurrence of a CAPRIN-1 expressing cancer, comprising administering to a subject an antibody or a fragment thereof having immunological reactivity with a polypeptide that consists of the amino acid sequence of SEQ ID NO:
A method for treating and/or preventing recurrence of a CAPRIN-1 expressing cancer, comprising administering to a subject a pharmaceutical combination comprising an antitumor agent, and
A method for treating and/or preventing recurrence of a CAPRIN-1 expressing cancer, comprising
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