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US 8,911,739 B2Granted
Methods of preventing rejection of transplanted tissue by administering anti-CD40L antibody and dendritic cells loaded with Hsp60sp peptide
AssigneesThe Trustees of Columbia University in the City of New York, National Institutes of Health (NIH)
InventorsHong Jiang, Leonard Chess
Life of this patent
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Abstract
A method is provided for preventing rejection by an immune system of a recipient subject of a tissue transplanted from a donor subject into the recipient subject without the need for long-term administration of non-specific immunosuppressive drugs.
Claims12
A method for preventing rejection of a tissue transplanted from a donor subject into a recipient subject comprising:
- a) administering to the recipient subject, prior to transplantation of the tissue, (i) a plurality of peripheral blood mononuclear cells (PBMCs) from the donor subject, wherein the PBMCs have been irradiated and do not proliferate in vivo, and (ii) an anti-CD40 ligand (anti-CD40L) antibody;
- and
- b) administering to the recipient subject, subsequent to transplantation of the tissue, dendritic cells loaded with Hsp60sp peptide wherein the Hsp60sp peptide comprises the amino acid sequence set forth in SEQ ID NO:2 or in SEQ ID NO:3.
Dependencies are inferred from the claim text.