Stem cell factor inhibitor
AssigneeThe Regents of the University of Michigan
InventorsNicholas W. Lukacs, Vladislav Dolgachev, Steven L. Kunkel, Cory M. Hogaboam, Sem H. Phan
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Abstract
Provided herein are methods, compositions, and uses relating to inhibitors of stem cell factor. For example, provided herein are antibodies targeting stem cell factor and methods for treating fibrotic and tissue remodeling diseases.
Claims39
A method of treating a disease that is a fibrotic disease or a tissue remodeling disease comprising administering a therapeutically effective amount of an anti-stem cell factor monoclonal antibody that specifically binds to SEQ ID NO:
- 1 or an antigen-binding fragment of said anti-stem cell factor monoclonal antibody to a subject with or at risk for a disease that is a fibrotic disease or a tissue remodeling disease.
A method comprising providing an anti-stem cell factor monoclonal antibody that specifically binds to SEQ ID NO:
- 1 or an antigen-binding fragment of said anti-stem cell factor monoclonal antibody and administering the anti-stem cell factor monoclonal antibody or the antigen-binding fragment of said anti-stem cell factor monoclonal antibody to a cell or tissue.
A method of treating a disease that is idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, acute respiratory distress syndrome, peribronchial fibrosis, hypersensitivity pneumonitis, sclerodoma, renal fibrosis, hepatic fibrosis, fibromyalgia, or radiation-induced fibrosis, the method comprising administering a therapeutically effective amount of an anti-stem cell factor monoclonal antibody or an antigen-binding fragment of said anti-stem cell factor monoclonal antibody to a subject having or at risk for having the disease that is idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, acute respiratory distress syndrome, peribronchial fibrosis, hypersensitivity pneumonitis, sclerodoma, renal fibrosis, hepatic fibrosis, fibromyalgia, or radiation-induced fibrosis.
A method of treating a disease that is a fibrotic disease or a tissue remodeling disease comprising administering a therapeutically effective amount of an anti-stem cell factor monoclonal antibody that specifically binds to a transmembrane form of stem cell factor or an antigen-binding fragment of said anti-stem cell factor monoclonal antibody to a subject with or at risk for a disease that is a fibrotic disease or a tissue remodeling disease.
Dependencies are inferred from the claim text.