Co-targeting of aurora A kinase and LIM kinase 1 for cancer therapy
AssigneeUniversity of Central Florida Research Foundation, Inc.
InventorRatna Chakrabarti
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Abstract
Disclosed herein are therapies for treating or preventing reoccurrence of cancer. The therapies involved inhibition of LIMK1 in conjunction with AurKA inhibition. Specifically exemplified herein is the administration of an AurKA inhibitor in conjunction with a LIMK1 RNA interfering molecule.
Claims4
A method for treating prostate cancer in a subject, said method comprising administering a therapeutically effective amount of a LIM kinase 1 (LIMK1) inhibitor and an Aurora Kinase A (AurKA) inhibitor to said subject, wherein said LIMK1 inhibitor comprises an antibody that binds to LIMK1, and the AurKA inhibitor comprises MLN8237 or an antibody that binds to AurKA.
Dependencies are inferred from the claim text.