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US 8,911,717 B2Granted
Polymalic acid-based multifunctional drug delivery system
AssigneesCedars-Sinai Medical Center, Arrogene Nanotechnology, Inc.
InventorsJulia Y. Ljubimova, Keith L. Black, Eggehard Holler
Life of this patent
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Abstract
A drug delivery system for delivering a drug payload to a specific tissue or cell type is disclosed. The system includes a polymalic acid molecular scaffold which can be used for attaching a plurality of molecular modules. Molecular modules include targeting antibodies for promoting cellular uptake by a target cell, and pro-drugs for altering cellular metabolism, for example, a pro-drug that alters expression of protein kinase CK2.
Claims20
A drug delivery system comprising:
- a polymerized polymalic acid molecular scaffold having a plurality of pendant carboxylic acid groups;
- a plurality of biologically active molecular modules, wherein each module is covalently linked to a pendant carboxylic acid of the polymerized polymalic acid molecular scaffold, wherein the biologically active molecular modules comprise:
- at least one targeting antibody for promoting cellular uptake by a target cell;
- and at least one pro-drug for altering cellular metabolism of the target cell, wherein the at least one pro-drug includes a pro-drug that alters expression of protein kinase CK2 and the at least one targeting antibody binds to bradykinin receptors, or an EGF receptor.
1 more element
Dependencies are inferred from the claim text.